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DNA Methylation Detection Kit for Human SDC2, SEPTIN9 and TFPI2 Gene -- COLC (Colorectal Cancer)

DNA Methylation Detection Kit for Human PCDH17, POU4F2 and PENK Gene -- BLAC (Bladder Cancer)

DNA Methylation Detection Kit for Human PAX1, SOX1 and HAS1 Gene -- CERC (Cervical Cancer)

DNA Methylation Detection Kit for Human PCDH17, POU4F2 and PENK Gene -- BLAC (Bladder Cancer)

Clinical Application

Bladder cancer is one of the most common malignancies but the corresponding diagnostic methods are either invasive or limited in specificity and/or sensitivity. DNA methylation is present in all bladder tumors and can be detected in urine specimens.

DNA Methylation can be a novel marker of prognosis for tumor therapy, which is also a reversible process in which inactivated tumor suppressor genes are expressed through demethylation to exert a tumor suppressor effect. Therefore, demethylation can be used as a new direction in cancer treatment to monitor the dynamics of the disease.

Intended Use

This kit is a real-time PCR assay for qualitative detection of DNA methylation in gene PCDH17, POU4F2 and PENK in human genomic DNA extracted from stool sample.